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CJC-1295 (no DAC) / Mod GRF 1-29 vs Sermorelin

Q: What is the difference between CJC-1295 (no DAC) / Mod GRF 1-29 and Sermorelin?

CJC-1295 (no DAC) / Mod GRF 1-29 is a Growth Hormone Secretagogue compound (Subcutaneous route) - GHRH analog without albumin binding. Very short half-life — preserves the natural GH pulse pattern. Sermorelin is a Growth Hormone Secretagogue compound (Subcutaneous route) - Recombinant GHRH 1-29. Published protocols typically schedule administration at bedtime to align with the natural overnight GH pulse.

Q: Which has a longer half-life, CJC-1295 (no DAC) / Mod GRF 1-29 or Sermorelin?

CJC-1295 (no DAC) / Mod GRF 1-29 has the longest published plasma half-life (~30 min), compared with Sermorelin (~12 min).

Q: How often is each compound dosed in the research literature?

CJC-1295 (no DAC) / Mod GRF 1-29: three times daily at a published dose range of 0.1–0.2 mg; Sermorelin: once daily at a published dose range of 0.1–0.5 mg. These are descriptive reference parameters, not dosing recommendations.

Q: Can you buy CJC-1295 (no DAC) / Mod GRF 1-29 and Sermorelin for research use?

Yes - CJC-1295 (no DAC) / Mod GRF 1-29, Sermorelin are available from New-U Research Compounds as lab-verified (>99% HPLC) compounds.

Published pharmacokinetic and receptor-characteristic comparison with primary-source references.

Updated August 2026 Research use only

CJC-1295 (NO DAC) / MOD GRF 1-29

CJC-1295 (no DAC) / Mod GRF 1-29

Growth Hormone Secretagogue

SERMORELIN

Sermorelin

Growth Hormone Secretagogue

Key research differences

CJC-1295 (no DAC) / Mod GRF 1-29 Sermorelin Receptor profile Growth Hormone Secretagogue Growth Hormone Secretagogue Development status Research peptide Research peptide Published half-life ~30 min ~12 min Research distinction GHRH analog without albumin binding. Very short half-life — preserves the natural GH pulse pattern Recombinant GHRH 1-29. Published protocols typically schedule administration at bedtime to align with the natural overnight GH pulse

Published research parameters

CJC-1295 (no DAC) / Mod GRF 1-29 Modified GRF 1-29, Sermorelin analog View CJC-1295 (no DAC) / Mod GRF 1-29 → Sermorelin GHRH 1-29 View Sermorelin → Receptor profile Growth Hormone Secretagogue Growth Hormone Secretagogue Class Growth Hormone Secretagogue Growth Hormone Secretagogue Plasma half-life ~30 min ~12 min Time to Cmax ~15 min ~6 min Development status Research peptide Research peptide Study context Peer-reviewed human PK Peer-reviewed human PK Primary publications Ionescu M & Frohman LA, J Clin Endocrinol Metab 91:4792 (2006) Walker RF, Clin Interv Aging 1:307 (2006) Summary GHRH analog without albumin binding. Very short half-life — preserves the natural GH pulse pattern. Recombinant GHRH 1-29. Published protocols typically schedule administration at bedtime to align with the natural overnight GH pulse.

View published study parameters

CJC-1295 (no DAC) / Mod GRF 1-29 Modified GRF 1-29, Sermorelin analog View CJC-1295 (no DAC) / Mod GRF 1-29 → Sermorelin GHRH 1-29 View Sermorelin → Route in published studies Subcutaneous Subcutaneous Published study interval Three times daily Once daily Published dose range 0.1–0.2 mg 0.1–0.5 mg Published study regimen No published study ladder No published study ladder

Source references

Ionescu M & Frohman LA

2006

Ionescu M & Frohman LA, J Clin Endocrinol Metab 91:4792 (2006)

Walker RF

2006

Walker RF, Clin Interv Aging 1:307 (2006)

Frequently asked questions

What is the difference between CJC-1295 (no DAC) / Mod GRF 1-29 and Sermorelin?

Which has a longer half-life, CJC-1295 (no DAC) / Mod GRF 1-29 or Sermorelin?

How often is each compound dosed in the research literature?

Can you buy CJC-1295 (no DAC) / Mod GRF 1-29 and Sermorelin for research use?

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Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.

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