What is Thymosin Alpha-1?

Thymosin Alpha-1 is a 28-amino acid peptide naturally produced by the thymus gland. It is the active component of Zadaxin (thymalfasin), approved in over 35 countries for hepatitis B/C treatment and as a cancer immunotherapy adjuvant.

How is Thymosin Alpha-1 different from TB-500 (Thymosin Beta-4)?

Despite both originating from the thymus, they have entirely different mechanisms. Thymosin Alpha-1 modulates immune function (T-cells, NK cells, dendritic cells), while TB-500 promotes tissue repair, cell migration, and angiogenesis. They are complementary, not interchangeable.

Is Thymosin Alpha-1 approved for clinical use anywhere?

Yes. As Zadaxin (thymalfasin), it is approved in over 35 countries - primarily in Asia, South America, and parts of Europe - for chronic hepatitis B, hepatitis C, and as an immune adjuvant in cancer treatment. It is not FDA-approved in the United States.

Can Thymosin Alpha-1 be stacked with other immune peptides?

Yes. Common research stacks include LL-37 for antimicrobial synergy, BPC-157 for immune + tissue repair, and KPV for combined immune modulation and anti-inflammatory effects.

What does "immunomodulator" mean versus "immunostimulant"?

An immunostimulant broadly revs up immune activity; an immunosuppressant broadly shuts it down. An immunomodulator (like Tα1) rebalances - it can amplify weak responses in immune-exhausted states like chronic viral infection, while calming overactivation in conditions like sepsis. The same molecule does both because the immune system regulates itself differently in different states.

How does Thymosin Alpha-1 differ from Thymulin or Thymopoietin?

They are all thymic peptides but completely different molecules with different mechanisms. Tα1 is a 28-residue peptide derived from prothymosin alpha that binds TLRs and supports T-cell maturation. Thymulin is a nonapeptide that requires zinc for activity, and thymopoietin is a 49-residue polypeptide. They are sometimes grouped together as "thymic factors" but act distinctly.

What is the typical research dose?

The standard clinical dose is 1.6 mg (approximately 900 μg/m² of body surface area) administered subcutaneously twice weekly. This is the dose used in most of the sepsis, hepatitis B, and immune support clinical trials. Research protocols often mirror this schedule.

How should Thymosin Alpha-1 be stored?

Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. Tα1 is reasonably stable in solution within the normal peptide-handling window.

Lyophilised · batch-documented · discreet packaging

>99% Purity // Janoshik Verified // Endogenous Thymic Peptide // 28 Amino Acids

Thymosin Alpha

Name: Thymosin Alpha-1
Brand: New-U Research Peptides
SKU: thymosin-alpha-1
Availability: InStock

Thymalfasin / Zadaxin // CAS 62304-98-7 // Immune Modulator

The thymus gland's master immune regulator. Approved in 35+ countries for viral hepatitis and cancer immunotherapy.

Thymosin Alpha-1 is a 28-amino acid peptide naturally secreted by the thymus gland. Commercially available as Zadaxin (thymalfasin), it is approved in over 35 countries for hepatitis B, hepatitis C, and as an immunotherapy adjuvant for cancer patients. It enhances T-cell maturation, NK cell activity, and dendritic cell function, improving both innate and adaptive immune responses. One of the few research peptides with extensive clinical approval data worldwide.

35+ Countries approved

28 Amino acids

Zadaxin Commercial name

6–12 Months Typical protocol length

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Every batch independently verified by Janoshik & Freedom Diagnostics for purity and identity.

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Uniform vial presentation, consistent labeling, and batch-level documentation every time.

10-vial pack

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Research use only. All compounds are sold strictly for in-vitro research and educational purposes. Not approved for human use, therapeutic application, or as food or cosmetic products. By purchasing, you agree to use these products only for legitimate research purposes.

Thymosin Alpha

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